Previous   Parent   Next   

(1990 Hecht et al.) De novo design of a native-like protein

Reports the de novo design, synthesis, and characterization of an antiparallel four-helix bundle protein containing 79 amino acid residues, containing a designed intramolecular disulfide bond linking the first and fourth helices.

With link to abstract:

Hecht MH, Richardson JS, Richardson DC, Ogden RC. (1990) “De novo design, expression, and characterization of Felix: a four-helix bundle protein of native-like sequence” Science 249:884-91.