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(1998 Benner et al.) New building blocks for nucleic acid engineering

Reports the use of synthetic organic chemistry to systematically modify the structure of DNA and RNA oligonucleotides, yielding 12 replicatable letters (vs. 4 in natural DNA), and modified backbones. This work extends the set of building blocks available for nucleic acid engineering.

With link to abstract:

Benner SA, et al. (1998) “Redesigning nucleic acids” Pure Appl Chem. 70:263-6.